The design, synthesis, and development of novel non-steroidal anti-inflammatory drugs (NSAIDs) with better activity and lower\nside effects are respectable area of research. Novel Diclofenac Schiff �s bases (M1, M2, M4, M7, and M8) were designed and\nsynthesized, and their respective chemical structures were deduced using various spectral tools (IR, 1HNMR, 13CNMR, and MS).\nThe compounds were synthesized via Schiff �s condensation reaction and their anti-inflammatory activity was investigated applying\nthe Carrageenan-induced paw edema model against Diclofenac as positive control. Percentage inhibition of edema indicated that\nall compounds were exhibiting a comparable anti-inflammatory activity as Diclofenac. Moreover, the anti-inflammatory activity\nwas supported via virtual screening usingmolecular docking study. Interestingly compound M2 showed the highest in vivo activity\n(61.32% inhibition) when compared to standard Diclofenac (51.36% inhibition) as well as the best binding energy score (-10.765)\nand the virtual screening docking score (-12.142).
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